Keanu Reeves

John Constantine

Suzanne Whang

Mother

Alice Lo

Old Woman

Nicholas Downs

Church Attendant

Ann Ryerson

Old Woman on Bus

Laz Alonso

Morgue Security Guard

Jeremy Ray Valdez

Liquor Store Clerk Nico

Barbara Pilavin

Old Woman on Bus (Demon)

C.W. Pyun

Korean Man

Sharon Omi

Female Tenant

Michelle Monaghan

Ellie (uncredited)

R. A. Rondell

Man in Jeep (uncredited)

Francis Guinan

Father Garret

Larry Cedar

Vermin Man

Rachel Weisz

Angela Dodson / Isabel Dodson

Shia LaBeouf

Chas Kramer

Djimon Hounsou

Midnite

Max Baker

Beeman

Pruitt Taylor Vince

Father Hennessy

Gavin Rossdale

Balthazar