Tobin Bell

Jigsaw/John

Janet Land

Morgan

Ron Lea

Rex

Joanne Boland

Crime Scene Photographer

Devon Bostick

Derek

Tony Nappo

Gus

Emmanuelle Vaugier

Addison Corday

Noam Jenkins

Michael Marks

Mike Butters

Paul Leahy

J. LaRose

Troy

Kim Roberts

Nurse Deborah

David Webster

Dr. Steve

Darrell Dennis

Additional Voice Talent (voice)

Tracey Ferencz

Additional Voice Talent (voice)

Christopher Marren

Additional Voice Talent (voice) (as Chris Marren)

Niamh Wilson

Corbett Denlon

Ingrid Hart

Tracy Rigg

Julian Richings

Vagrant

Costas Mandylor

Hoffman

Scott Patterson

Agent Strahm