Tom Holland

Peter Parker / Spider-Man

Zendaya

MJ

Mark Ruffalo

Bruce Banner / Hulk

Jon Bernthal

Frank Castle / Punisher

Jacob Batalon

Ned Leeds

Sadie Sink

Jean Grey

Florence Pugh

Yelena Belova / Black Widow

Liza Colón-Zayas

Detective Jean DeWolff

Tramell Tillman

William 'Bill' Metzger

Marisa Tomei

May Parker

Naomi Watts

E.V. (voice)

Michael Mando

Mac Gargan / Scorpion

Keith David

Narrator of Spider Video (voice)

Marvin 'Krondon' Jones III

Tombstone

Olivia Booth-Ford

Sara

Taryn Marie Butler

Apartment Girl

Johnny Myers

Building Manager

Billy Clements

Ramrod

Zabryna Guevara

Sheila Rivera

Nina Rose Galano

Marley