Michael J. Fox

Stuart Little (voice)

Allyce Beasley

Beatrice Little

Brian Doyle-Murray

Edgar Little

Estelle Getty

Estelle Little

Harold Gould

Spencer Little

Patrick Thomas O'Brien

Uncle Stretch

Julia Sweeney

Mrs. Keeper

Dabney Coleman

Dr. Beechwood

Miles Marsico

Anton

Jon Polito

Detective Sherman

Joe Bays

Race Starter

Taylor Negron

Salesman in Mall

Connie Ray

Tina Little

Jeffrey Jones

Crenshaw Little

Chazz Palminteri

Smokey (voice)

Nathan Lane

Snowbell (voice)

Geena Davis

Mrs. Eleanor Little

Hugh Laurie

Mr. Fredrick Little

Jonathan Lipnicki

George Little

David Alan Grier

Red (voice)