Emma Thompson

Nanny McPhee

Claire Downes

Nanny Whetstone

Adam Godley

Vicar

Patrick Barlow

Mr. Jowls

Derek Jacobi

Mr. Wheen

Elizabeth Berrington

Letita

Imelda Staunton

Mrs. Blatherwick

Celia Imrie

Mrs. Quickly

Angela Lansbury

Aunt Adelaide

Hebe Barnes

Baby Agatha

Holly Gibbs

Christianna

Samuel Honywood

Sebastian

Raphaël Coleman

Eric

Jennifer Rae Daykin

Lily

Eliza Bennett

Tora

Thomas Brodie-Sangster

Simon

Kelly Macdonald

Evangeline

Colin Firth

Mr. Brown

Phyllida Law

Mrs. Partridge (voice)