Anthony Hopkins

Hannibal Lecter

Bill Duke

Police Chief

Azura Skye

Bookseller

Stanley Anderson

Jimmy Price

Jeanine Jackson

Dr. Hassler

Ellen Burstyn

Grandma Dolarhyde (voice) (uncredited)

Mary Beth Hurt

Museum Curator (uncredited)

James Pickens Jr.

Male Zoo Doctor (uncredited)

Frank Whaley

Ralph Mandy (uncredited)

Tanya Newbould

Chromalux Secretary

Katie Rich

Woman Detective

Tom Verica

Charles Leeds

Marguerite MacIntyre

Valerie Leeds

Elizabeth Dennehy

Beverly

William Lucking

Byron Metcalf

Mark Moses

Father in Video

Madison Mason

Police Commissioner

Michael Cavanaugh

Forensic Dentist

Edward Norton

Will Graham

Ralph Fiennes

Francis Dolarhyde